Substrate: Ribosomal protein S6 kinase 1 (p70 S6 kinase)
Seq-ID: P23443 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14377   PDPK1_HUMAN
MINT-14953   4EBP1_MOUSE
MINT-15213   AKT1_HUMAN
MINT-15292   CDC42_HUMAN
MINT-51122   COASY_HUMAN
MINT-74872   TAU_HUMAN
MINT-74874   TAU_HUMAN
MINT-3390512   PDK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ATP binding,
protein kinase activity,
protein binding		 cell junction,
cytoplasm,
cytosol,
synapse,
mitochondrial outer membrane,
synaptosome,
nucleus		 TOR signaling cascade,
negative regulation of apoptosis,
positive regulation of mitotic cell cycle,
apoptosis,
G1/S transition of mitotic cell cycle,
phosphoinositide-mediated signaling,
positive regulation of translational initiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 53 ELEEGGQLNESMDHGGVGPYE - 12023960
LTP
0.02
 - -
0.65
 - low
T 252 ESIHDGTVTHTFCGTIEYMAP PDK-1 9445476
LTP
0.96
 - S_TKc
0.15
 - low
T 390 SQFDSKFTRQTPVDSPDDSTL - 9271440
LTP
0.84
 - S_TK_X
0.66
 - low
T 390 SQFDSKFTRQTPVDSPDDSTL mTOR 12370290
LTP
0.84
 - S_TK_X
0.66
 - low
T 390 SQFDSKFTRQTPVDSPDDSTL - 9465032
LTP
0.84
 - S_TK_X
0.66
 - low
T 390 SQFDSKFTRQTPVDSPDDSTL - 11914378
LTP
0.84
 - S_TK_X
0.66
 - low
T 390 SQFDSKFTRQTPVDSPDDSTL mTOR 14560963
LTP
0.84
 - S_TK_X
0.66
 - low
T 390 SQFDSKFTRQTPVDSPDDSTL - 18669648
HTP
0.84
 - S_TK_X
0.66
 - low
S 394 SKFTRQTPVDSPDDSTLSESA CDK1 12586835
LTP
0.98
 - S_TK_X
0.70
 - low
S 394 SKFTRQTPVDSPDDSTLSESA mTOR 11914378
LTP
0.98
 - S_TK_X
0.70
 - low
S 394 SKFTRQTPVDSPDDSTLSESA - 14993219
LTP
0.98
 - S_TK_X
0.70
 - low
S 394 SKFTRQTPVDSPDDSTLSESA - 18669648
HTP
0.98
 - S_TK_X
0.70
 - low
S 403 DSPDDSTLSESANQVFLGFTY - 12023960
LTP
0.85
 - S_TK_X
0.41
 - low
T 412 ESANQVFLGFTYVAPSVLESV - 12023960
LTP
0.94
 - S_TK_X
0.23
 - low
T 412 ESANQVFLGFTYVAPSVLESV - 11914378
LTP
0.94
 - S_TK_X
0.23
 - low
T 412 ESANQVFLGFTYVAPSVLESV - 16099428
LTP
0.94
 - S_TK_X
0.23
 - low
T 412 ESANQVFLGFTYVAPSVLESV mTOR 15809305
LTP
0.94
 - S_TK_X
0.23
 - low
T 412 ESANQVFLGFTYVAPSVLESV mTOR 15718470
LTP
0.94
 - S_TK_X
0.23
 - low
T 412 ESANQVFLGFTYVAPSVLESV PDK-1 15388791
LTP
0.94
 - S_TK_X
0.23
 - low
T 412 ESANQVFLGFTYVAPSVLESV p70S6K 15388791
LTP
0.94
 - S_TK_X
0.23
 - low
T 412 ESANQVFLGFTYVAPSVLESV PDK-1 12183455
LTP
0.94
 - S_TK_X
0.23
 - low
T 412 ESANQVFLGFTYVAPSVLESV p70S6K 12183455
LTP
0.94
 - S_TK_X
0.23
 - low
S 427 SVLESVKEKFSFEPKIRSPRR PDK-1 9271440
LTP
0.37
 - -
0.40
 - low
S 434 EKFSFEPKIRSPRRFIGSPRT - 9271440
LTP
0.44
 MOD_CDK_SPxK_1
 - -
0.49
 - low
S 434 EKFSFEPKIRSPRRFIGSPRT CDK1 12586835
LTP
0.44
 MOD_CDK_SPxK_1
 - -
0.49
 - low
S 434 EKFSFEPKIRSPRRFIGSPRT - 11914378
LTP
0.44
 MOD_CDK_SPxK_1
 - -
0.49
 - low
S 434 EKFSFEPKIRSPRRFIGSPRT - 14993219
LTP
0.44
 MOD_CDK_SPxK_1
 - -
0.49
 - low
S 434 EKFSFEPKIRSPRRFIGSPRT - 15208671
LTP
0.44
 MOD_CDK_SPxK_1
 - -
0.49
 - low
S 434 EKFSFEPKIRSPRRFIGSPRT mTOR 15809305
LTP
0.44
 MOD_CDK_SPxK_1
 - -
0.49
 - low
S 441 KIRSPRRFIGSPRTPVSPVKF - 9271440
LTP
0.41
 - -
0.55
 - low
S 441 KIRSPRRFIGSPRTPVSPVKF - 17081983
HTP
0.41
 - -
0.55
 - low
S 441 KIRSPRRFIGSPRTPVSPVKF - 18669648
HTP
0.41
 - -
0.55
 - low
T 444 SPRRFIGSPRTPVSPVKFSPG CDK1 12586835
LTP
0.38
 MOD_CDK_SPxK_1
 - -
0.50
 - low
T 444 SPRRFIGSPRTPVSPVKFSPG - 11914378
LTP
0.38
 MOD_CDK_SPxK_1
 - -
0.50
 - low
T 444 SPRRFIGSPRTPVSPVKFSPG - 17081983
HTP
0.38
 MOD_CDK_SPxK_1
 - -
0.50
 - low
T 444 SPRRFIGSPRTPVSPVKFSPG - 18669648
HTP
0.38
 MOD_CDK_SPxK_1
 - -
0.50
 - low
S 447 RFIGSPRTPVSPVKFSPGDFW CDK1 12586835
LTP
0.41
 MOD_CDK_SPxK_1
 - -
0.48
 - low
S 447 RFIGSPRTPVSPVKFSPGDFW CDK1 11914378
LTP
0.41
 MOD_CDK_SPxK_1
 - -
0.48
 - low
S 447 RFIGSPRTPVSPVKFSPGDFW mTOR 11914378
LTP
0.41
 MOD_CDK_SPxK_1
 - -
0.48
 - low
S 447 RFIGSPRTPVSPVKFSPGDFW - 17081983
HTP
0.41
 MOD_CDK_SPxK_1
 - -
0.48
 - low
S 447 RFIGSPRTPVSPVKFSPGDFW - 16964243
HTP
0.41
 MOD_CDK_SPxK_1
 - -
0.48
 - low
S 447 RFIGSPRTPVSPVKFSPGDFW - 18669648
HTP
0.41
 MOD_CDK_SPxK_1
 - -
0.48
 - low
S 452 PRTPVSPVKFSPGDFWGRGAS - 18669648
HTP
0.43
 - -
0.51
 - low
T 470 GASASTANPQTPVEYPMETSG - 9271440
LTP
0.13
 - -
0.77
 - low

Substrate: Ribosomal protein S6 kinase 1 (p70 S6 kinase)
Seq-ID: Q8BSK8 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ATP binding cell junction,
synapse,
mitochondrial outer membrane,
synaptosome		 protein amino acid phosphorylation,
negative regulation of apoptosis,
apoptosis,
germ cell development,
protein kinase B signaling cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 53 ELEEGGQLNESMDHGGVEPYE NEK6 12023960
LTP
0.02
 - -
0.64
 - low
T 252 ESIHDGTVTHTFCGTIEYMAP - 17141160
LTP
0.96
 - S_TKc
0.15
 - low
T 252 ESIHDGTVTHTFCGTIEYMAP - 18347057
LTP
0.96
 - S_TKc
0.15
 - low
T 390 SQFDSKFTRQTPVDSPDDSTL - 15799971
LTP
0.82
 - S_TK_X
0.65
 - low
S 394 SKFTRQTPVDSPDDSTLSESA NEK6 12023960
LTP
0.98
 - S_TK_X
0.70
 - low
S 398 RQTPVDSPDDSTLSESANQVF NEK6 12023960
LTP
0.49
 - S_TK_X
0.62
 - low
S 403 DSPDDSTLSESANQVFLGFTY NEK6 12023960
LTP
0.85
 - S_TK_X
0.41
 - low
T 412 ESANQVFLGFTYVAPSVLESV NEK6 12023960
LTP
0.94
 - S_TK_X
0.22
 - low
T 412 ESANQVFLGFTYVAPSVLESV NEK6 11516946
LTP
0.94
 - S_TK_X
0.22
 - low
T 412 ESANQVFLGFTYVAPSVLESV - 17141160
LTP
0.94
 - S_TK_X
0.22
 - low
T 470 GASASTANPQTPVEYPMETSG - 7489717
LTP
0.13
 - -
0.77
 - low

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